Ergotamine derivatives: As utile link a result of the theoretic chances of ergotism, the fresh concurrent the means to access azithromycin that have ergot types is not needed (select part 4.4).
No matter if neutropenia could have been in the use of rifabutin, a beneficial causal link to integration which have azithromycin has not been depending (find Section 4
Alerting is preferred in the co-government of them drugs that have Azithromycin of the known boosting effectation of this type of drugs whenever made use of concurrently to the macrolid antibiotic drug erythromycin.
Co-government of atorvastatin (ten milligrams everyday) and you will azithromycin (five-hundred milligrams daily) didn’t replace the plasma concentrations away from atorvastatin (centered on a HMG CoA-reductase inhibition assay). But not, post-selling cases of rhabdomyolysis into the customers searching azithromycin which have statins has actually come claimed.
Within the an excellent pharmacokinetic telecommunications investigation in healthy volunteers, zero extreme feeling try observed toward plasma degrees of carbamazepine otherwise its productive metabolite into the customers finding concomitant azithromycin.
In the event an effective causal dating was not depending, planning shall be made available to the fresh volume out-of monitoring prothrombin date whenever azithromycin is used within the people receiving coumarin-kind of dental anticoagulants
Cisapride are metabolized regarding the liver from the chemical CYP 3A4. Just like the macrolides inhibit which chemical, concomitant management from cisapride might cause the rise regarding QT interval prolongation, ventricular arrhythmias and you will torsades de pointes.
When you look at the an excellent pharmacokinetic study investigating the results of 1 amount of cimetidine, provided couple of hours ahead of azithromycin, to your pharmacokinetics off azithromycin, zero customization off azithromycin pharmacokinetics is actually seen.
Within the a good pharmacokinetic correspondence study, azithromycin failed to alter the anticoagulant effectation of just one fifteen milligrams serving off warfarin given in order to compliment volunteers. There were reports gotten regarding article-sales chronilogical age of potentiated anticoagulation after co-government of azithromycin and you will coumarin-types of oral anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmax and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-government from a 600 mg single dose from azithromycin and you can 400 milligrams efavirenz every day to own seven days failed to lead to people clinically high pharmacokinetic relationships.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-management of 1 dose off 1200 mg azithromycin didn’t come with statistically extreme effect on new pharmacokinetics out-of indinavir administered given that 800 mg 3 x day-after-day for five weeks.
During the fit volunteers, co-government off azithromycin five-hundred milligrams/go out to possess 3 days did not bring about clinically high alterations in the new pharmacokinetics and you may pharmacodynamics of one fifteen milligrams serving away from midazolam.
Co-administration regarding azithromycin (1200 mg) and nelfinavir during the steady-state (750 mg three times daily) contributed to enhanced azithromycin levels. No medically high unwanted effects was in fact seen with no dose adjustment is required.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic research has said zero evidence of a conversation anywhere between azithromycin and you will terfenadine. There were rare cases reported where in fact the possibility of including a connection cannot getting totally excluded; not there’s zero particular facts one such as for instance a connections got occurred.